Mild Hyponatremia as a Risk Factor for Fractures: The Rotterdam Study
Mild Hyponatremia as a Risk Factor for Fractures: The Rotterdam Study
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DOI：
10.1002/jbmr.380
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发表时间：
2011-08-01
影响因子：
6.2
通讯作者：
Zillikens, M. Carola
中科院分区：
文献类型：
--
作者：
Hoorn, Ewout J.;Rivadeneira, Fernando;Zillikens, M. Carola
最近的研究表明轻度低钠血症与骨折有关，但缺乏前瞻性研究。我们研究了低钠血症是否与骨折、跌倒和/或骨密度（BMD）有关。基于前瞻性人群的鹿特丹研究共纳入5208名基线时血清钠评估的老年受试者。分析以下数据：骨密度、椎体骨折（平均随访6.4年）、非椎体骨折（7.4年）、近期跌倒、合并症、用药和死亡率。399例低钠血症（7.7%,133.4 +/- 2.0 mmol/L）。低钠血症患者年龄较大(73.5 +/- 10.3岁vs 70.0 +/- 9.0岁，p
Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking. We studied whether hyponatremia is associated with fractures, falls, and/or bone mineral density (BMD). A total of 5208 elderly subjects with serum sodium assessed at baseline were included from the prospective population-based Rotterdam Study. The following data were analyzed: BMD, vertebral fractures (mean follow-up 6.4 years), nonvertebral fractures (7.4 years), recent falls, comorbidity, medication, and mortality. Hyponatremia was detected in 399 subjects (7.7%, 133.4 +/- 2.0 mmol/L). Subjects with hyponatremia were older (73.5 +/- 10.3 years versus 70.0 +/- 9.0 years, p