RAMOPLANIN (A-16686), A NEW GLYCOLIPODEPSIPEPTIDE ANTIBIOTIC .3. STRUCTURE ELUCIDATION
RAMOPLANIN (A-16686), A NEW GLYCOLIPODEPSIPEPTIDE ANTIBIOTIC .3. STRUCTURE ELUCIDATION
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DOI：
10.7164/antibiotics.42.254
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发表时间：
1989-02-01
影响因子：
3.3
通讯作者：
CAVALLERI, B
中科院分区：
文献类型：
--
作者：
CIABATTI, R;KETTENRING, JK;CAVALLERI, B
通过化学、~1H、~(13)C核磁共振谱和质谱学相结合的方法，对放线菌产生的抗生素雷莫拉宁(A-16686)的三个组分的结构进行了研究。ATCC 33076，已被阐明。所有组分都具有由带有二甘露醇基团的公共去脂肽骨架形成的结构，并且通过存在来自C8、C9和C10脂肪酸的各种酰胺部分来区分。
By combination of chemical, 1H and 13C NMR, and mass specrometric studies, the structures of three components of the antibiotic ramoplanin (A-16686), produced by Actinoplanes sp. ATCC 33076, have been elucidated. All the components have structures formed by a common depsipeptide skeleton carrying a dimannosyl group and are differentiated by the presence of various acylamide moieties, derived from C8, C9 and C10 fatty acids.