Modeling of modifier-solute peak interactions in chromatography
Modeling of modifier-solute peak interactions in chromatography
复制标题
DOI：
10.1002/aic.10624
复制
发表时间：
2006-02
期刊：
影响因子：
3.7
通讯作者：
G. Ströhlein;M. Morbidelli;H. Rhee;M. Mazzotti
中科院分区：
文献类型：
--
作者：
G. Ströhlein;M. Morbidelli;H. Rhee;M. Mazzotti
在平衡理论的背景下，分析了在合适的改性剂存在下进料单一溶质的色谱柱的行为。特别是，溶质的脉冲传播（其保留取决于改性剂浓度）已通过应用于拟线性微分方程对的速图变换方法被分析为成熟的二元问题。已经表明，所有可能的操作条件都可以根据改性剂浓度归纳为三种情况。这些问题已经通过首先在光刻平面上构建解决方案，然后使用特征方法将其映射到物理平面上来解析解决。解释了所导出的光刻平面的特殊性质，并阐明了它们对三种不同情况下脉冲传播的影响。对于改性剂中等吸附性的情况，出现无限高浓度的溶质峰；即溶质脉冲，以及双溶质峰现象已被证明。
The behavior of a chromatographic column where a single solute is fed in the presence of a suitable modifier is analyzed in the context of equilibrium theory. In particular, the pulse propagation of the solute, whose retention depends on the modifier concentration, has been analyzed as a full-fledged binary problem by the method of hodograph transformation applied to the pair of quasilinear differential equations. It has been shown that all possible operating conditions can be summarized with respect to the modifier concentration into three cases. These have been solved analytically by constructing the solution first in the hodograph plane, and then mapping it onto the physical plane using the method of characteristics. The peculiar properties of the derived hodograph plane were explained, and their impact on the pulse propagation for the three different cases has been elucidated. For the cases of intermediate adsorptivity of the modifier, the occurrence of solute peaks with infinitely high concentrations; that is, solute impulse, has been proven as well as the phenomena of double solute peaks.