Tumor necrosis factor identified in multiple sclerosis brain.
Tumor necrosis factor identified in multiple sclerosis brain.
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DOI：
10.1084/jem.170.2.607
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发表时间：
1989-08-01
期刊：
影响因子：
--
通讯作者：
Merrill JE
中科院分区：
文献类型：
--
作者：
Hofman FM;Hinton DR;Johnson K;Merrill JE
使用免疫细胞化学技术对多发性硬化（MS）和其他神经系统疾病患者的冷冻脑标本进行肿瘤坏死因子（TNF）存在情况的分析。在多发性硬化的脑部病变以及亚急性硬化性全脑炎中，发现了TNF阳性细胞。在多发性硬化的病变部位，TNF阳性染色与星形胶质细胞和巨噬细胞均有关。在阿尔茨海默病或正常脑组织中未观察到这些现象。多发性硬化病变中TNF的存在表明细胞因子和免疫反应在疾病进展中具有重要作用。
Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF. In brain lesions in MS, and subacute sclerosing panencephalitis, TNF+ cells were demonstrated. At the lesion site in MS, TNF+ staining is associated with both astrocytes and macrophages. These observations were not made in Alzheimer's disease or normal brain tissue. The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progression.