Laser-ablation-assisted microparticle acceleration for drug delivery
Laser-ablation-assisted microparticle acceleration for drug delivery
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DOI：
10.1063/1.2093930
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发表时间：
2005-10-17
影响因子：
4
通讯作者：
Gopalan, J
中科院分区：
文献类型：
--
作者：
Menezes, V;Takayama, K;Gopalan, J
局部给药与最小的组织损伤是所需的一些临床程序，如基因治疗，治疗癌细胞，治疗血栓形成等，我们提出了一种有效的方法，用于提供药物涂层微粒使用激光烧蚀薄金属箔含有颗粒。沉积有微粒层的薄金属箔在其背面上经受激光烧蚀，使得冲击波传播通过箔。由于冲击波加载，含有微粒的箔的表面被加速到非常高的速度，以高超音速喷射沉积的颗粒。喷射的粒子具有足够的动量穿透软身体组织，并且观察到的穿透深度足以用于大多数药物治疗。我们已经尝试将1 μ m的钨颗粒输送到明胶模型中，该模型代表实验大鼠的软组织和肝组织。在这些实验中已经观察到足够的穿透深度，具有最小的目标损伤。(C)2005年美国物理学会。
Localized drug delivery with minimal tissue damage is desired in some of the clinical procedures such as gene therapy, treatment of cancer cells, treatment of thrombosis, etc. We present an effective method for delivering drug-coated microparticles using laser ablation on a thin metal foil containing particles. A thin metal foil, with a deposition of a layer of microparticles is subjected to laser ablation on its backface such that a shock wave propagates through the foil. Due to shock wave loading, the surface of the foil containing microparticles is accelerated to very high speeds, ejecting the deposited particles at hypersonic speeds. The ejected particles have sufficient momentum to penetrate soft body tissues, and the penetration depth observed is sufficient for most of the pharmacological treatments. We have tried delivering 1 mu m tungsten particles into gelatin models that represent soft tissues, and liver tissues of an experimental rat. Sufficient penetration depths have been observed in these experiments with minimum target damage. (C) 2005 American Institute of Physics.