Cingulate function in depression: A potential predictor of treatment response
Cingulate function in depression: A potential predictor of treatment response
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DOI：
10.1097/00001756-199703030-00048
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发表时间：
1997-03-03
期刊：
影响因子：
1.7
通讯作者：
Fox, PT
中科院分区：
文献类型：
--
作者：
Mayberg, HS;Brannan, SK;Fox, PT
采用正电子发射断层扫描（PET）对单相抑郁症住院患者治疗前局部脑葡萄糖代谢与最终抗抑郁药物反应之间的关系进行了测量。喙部前扣带代谢独特地区分最终治疗应答者和无应答者。与对照组相比，低代谢的特点是无反应者，而高代谢的反应者则相反。在其他地区的代谢没有区分这两组，也没有相关的人口统计学，临床或行为指标，包括运动速度，认知能力，抑郁症的严重程度或疾病的慢性化。扣带回代谢亢进可能是抑郁症的一种重要的适应性反应，这种反应的失败可能是不良结局的基础。一个关键的作用，喙扣带区24 a/B的边缘皮质网络参与异常情绪状态的建议。
THE relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.