Short-Term Contact Kinematic Changes and Longer-Term Biochemical Changes in the Cartilage After ACL Reconstruction: A Pilot Study.

Short-Term Contact Kinematic Changes and Longer-Term Biochemical Changes in the Cartilage After ACL Reconstruction: A Pilot Study.
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DOI:
10.1007/s10439-018-2079-6
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发表时间:
2018-11
影响因子:
3.8
通讯作者:
Hosseini A
Hosseini A
中科院分区:
工程技术2区
文献类型:
--
作者:
Li G;Li JS;Torriani M;Hosseini A

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研究前交叉韧带重建后软骨退行性变的发展,对改进当前前交叉韧带损伤的手术治疗,防止长期的膝关节退行性变具有重要意义。本初步研究考察了7例患者在ACL重建后6个月负重膝关节接触运动学变化与术后3年膝关节软骨生化成分变化之间的关系。分析表明,前交叉韧带重建后短期内膝关节接触运动学的改变与较长随访时间内软骨T2值升高有关。本研究的数据可以为未来的前瞻性、纵向研究和大患者群体的研究提供初步数据,以建立预测前交叉韧带重建后长期软骨退变的生物力学标志物。
Investigation of the development of cartilage degeneration after ACL reconstruction is important for improving current surgical treatment of ACL injuries to prevent long-term knee joint degeneration. This pilot study examined the relationship between the changes in weight-bearing knee contact kinematics 6 months after ACL reconstruction and the biochemical composition changes in the knee cartilage measured using T2 relaxation values 3 years after the surgery in seven patients. The analysis indicated that the change of the knee contact kinematics in short-term after ACL reconstruction is associated with an increase of T2 values of the cartilage in longer follow up times. The data of this study could provide preliminary data to power future studies that use prospective, longitudinal research and large patient populations to establish prognostic biomechanical markers for determination of long-term cartilage degeneration after ACL reconstruction.
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