CARTILAGINOUS TUMORS - CORRELATION OF GADOLINIUM-ENHANCED MR IMAGING AND HISTOPATHOLOGIC FINDINGS
CARTILAGINOUS TUMORS - CORRELATION OF GADOLINIUM-ENHANCED MR IMAGING AND HISTOPATHOLOGIC FINDINGS
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DOI：
10.1148/radiology.186.3.8430192
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发表时间：
1993-03-01
期刊：
影响因子：
19.7
通讯作者：
TAMINIAU, AHM
中科院分区：
文献类型：
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作者：
GEIRNAERDT, MJA;BLOEM, JL;TAMINIAU, AHM
钆增强磁共振（MR）图像与软骨肿瘤患者的组织病理学表现相关。对34例患者静脉注射钆喷酸葡胺前后获得的短重复时间/回波时间自旋回波MR图像进行了评价。27例低度恶性软骨肉瘤中有24例显示间隔强化。强化的弧形间隔由纤维血管组织构成。非强化区由少细胞透明软骨、囊状粘液组织和坏死组成。在三个良性骨软骨瘤和四个高级别软骨肉瘤中没有发现这种增强模式和相应的组织病理学表现。在所有高级别软骨肉瘤中，组织病理学分析显示与高细胞区域相关的不均匀或均匀增强。三个骨软骨瘤显示周边增强，与纤维血管组织覆盖的非增强软骨帽。作者得出结论，静脉注射钆喷酸葡胺后，MR图像上的间隔增强改善了软骨肿瘤的组织特征，可能有助于识别低级别软骨肉瘤。
Gadolinium-enhanced magnetic resonance (MR) images were correlated with histopathologic findings in patients with cartilaginous tumors. Short repetition time/echo time spin-echo MR images obtained before and after intravenous administration of gadopentetate dimeglumine in 34 patients were evaluated. Twenty-four of 27 low-grade chondrosarcomas showed septal enhancement. The enhancing curvilinear septa consisted of fibrovascular tissue. The nonenhancing areas consisted of paucicellular hyaline cartilage, cystic mucoid tissue, and necrosis. This enhancement pattern and corresponding histopathologic findings were not seen in three benign osteochondromas or four high-grade chondrosarcomas. Inhomogeneous or homogeneous enhancement correlating with highly cellular areas at histopathologic analysis was seen in all high-grade chondrosarcomas. The three osteochondromas showed peripheral enhancement that correlated with fibrovascular tissue covering the non-enhancing cartilage cap. The authors conclude that septal enhancement on MR images after intravenous administration of gadopentetate dimeglumine improves tissue characterization of cartilaginous tumors and may assist in identifying low-grade chondrosarcoma.