Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance.
Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance.
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DOI：
10.1155/2015/848710
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发表时间：
2015
影响因子：
--
通讯作者：
Singh AP
中科院分区：
文献类型：
--
作者：
Srivastava SK;Arora S;Averett C;Singh S;Singh AP
MicroRNAs （miRNAs）是一种小的内源性非编码rna，可调节多种生物过程，如分化、发育和生存。最近的研究表明，mirna在癌症中失调，并在癌症的发生、进展和化疗耐药中发挥关键作用。因此，利用mirna作为癌症预防和治疗的靶点可能是一种很有前途的方法。大量证据表明，许多天然存在的植物化学物质调节了许多参与癌症病理生物学的mirna的表达。因此，了解植物化学物质在癌症中对mirna的调控、其潜在的分子机制以及对肿瘤病理生理的功能影响，可能有助于制定对抗这种毁灭性疾病的新策略。本文对这些方面进行了讨论，目的是从翻译的角度强调这些观察结果的重要性。
MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that regulate a variety of biological processes such as differentiation, development, and survival. Recent studies suggest that miRNAs are dysregulated in cancer and play critical roles in cancer initiation, progression, and chemoresistance. Therefore, exploitation of miRNAs as targets for cancer prevention and therapy could be a promising approach. Extensive evidence suggests that many naturally occurring phytochemicals regulate the expression of numerous miRNAs involved in the pathobiology of cancer. Therefore, an understanding of the regulation of miRNAs by phytochemicals in cancer, their underlying molecular mechanisms, and functional consequences on tumor pathophysiology may be useful in formulating novel strategies to combat this devastating disease. These aspects are discussed in this review paper with an objective of highlighting the significance of these observations from the translational standpoint.
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