Low density lipoprotein inhibits accumulation of nitrites in murine brain endothelial cell cultures.
Low density lipoprotein inhibits accumulation of nitrites in murine brain endothelial cell cultures.
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DOI：
10.1016/s0006-291x(05)80809-5
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发表时间：
1992-07
影响因子：
3.1
通讯作者：
Michal Bereta;Joanna Bereta;Stanley Cohen;Marion C. Cohen
中科院分区：
文献类型：
--
作者：
Michal Bereta;Joanna Bereta;Stanley Cohen;Marion C. Cohen
Endothelial cells produce nitric oxide which is considered to serve as a major source of endothelial derived relaxing factor activity. It has been demonstrated that activation of mouse brain endothelium by TNF-α and IFN-γ led to accumulation of nitrite which is presumably formed by oxidation of nitric oxide. A number of studies suggest that reactive oxygen species produced by cytokine-activated cells are involved in the conversion of nitric oxide to nitrites and nitrates. We investigated whether low density lipoprotein (LDL), acting as a radical scavenger, is able to inhibit nitrite accumulation in mouse brain endothelial cell cultures and in a cell-free system in which sodium nitroprusside was used as a source of nitric oxide. A comparison of these two models indicates the active involvement of LDL in suppressing nitrite accumulation in murine endothelial cultures.
