Predisposition of Women to Cardiovascular Diseases: A Side-Effect of Increased Glucocorticoid Signaling During the COVID-19 Pandemic?
Predisposition of Women to Cardiovascular Diseases: A Side-Effect of Increased Glucocorticoid Signaling During the COVID-19 Pandemic?
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DOI：
10.3389/fgwh.2021.606833
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cruz-Topete D
中科院分区：
文献类型：
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作者：
Dhaibar HA;Cruz-Topete D
新型冠状病毒病2019年(新冠肺炎)大流行在全球范围内造成了严重的健康危机。为了减少这种疾病的传播，已经实施了“社会距离”和“就地避难所”。虽然这些行动对控制疫情至关重要，但由于压力增加，它们会产生短期和长期的心理健康后果。精神压力和心血管疾病(CVD)之间有很强的关联性。与年龄匹配的男性相比，年轻女性(绝经前)因精神压力而发生心血管事件的风险很高。女性对压力的反应和反应增加的机制大多是未知的。本文综述了已知的心理应激对女性心血管系统的生理影响，以及主要应激激素糖皮质激素对心血管系统作用的最新分子研究结果。目前的数据表明，心理压力和心脏病之间存在明显的联系，女性对压力荷尔蒙信号失衡的有害影响更加敏感。因此，预计随着新冠肺炎疫情带来的前所未有的压力，女性的简历健康将受到严重影响。关键是要扩大我们对精神压力对女性心血管疾病风险的直接贡献的理解，并在有或没有心血管疾病的女性患者中确定对心血管疾病具有预测价值的生化标志物，这些患者在当前的流行病中经历了重大的精神压力。
The novel coronavirus disease 2019 (COVID-19) pandemic has created a significant health crisis worldwide. To mitigate this disease's spread, “social distancing” and “shelter in place” have been implemented. While these actions have been critical to controlling the pandemic, they have short- and long-term mental health consequences due to increased stress. There is a strong association between mental stress and cardiovascular disease (CVD). Young women (pre-menopausal) are at high risk of developing CV events in response to mental stress compared to age-matched men. The mechanisms underlying women's increased reactivity and response to stress are mostly unknown. The present review summarizes the known physiological consequences of mental stress in women's CV health and the latest molecular findings of the actions of the primary stress hormones, glucocorticoids, on the CV system. The current data suggest a clear link between psychological stress and heart disease, and women have an increased sensitivity to the harmful effects of stress hormone signaling imbalances. Therefore, it is expected that with the given unprecedented levels of stress associated with the COVID-19 pandemic, women's CV health will be significantly compromised. It is critical to widen our understanding of the direct contribution of mental stress to CVD risk in women and to identify biochemical markers with predictive value for CVD in female patients with/without cardiovascular conditions who have experienced significant mental stress during the current pandemic.