Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea
Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea
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DOI：
10.1242/dev.137976
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发表时间：
2016-05
期刊：
影响因子：
4.6
通讯作者：
Z. Stojanova;Tao Kwan;N. Segil
中科院分区：
文献类型：
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作者：
Z. Stojanova;Tao Kwan;N. Segil
开发 142, 3529-3536 中发布了一个错误。两种药物的浓度报告错误。正确的值为 200 nM（不是 500 μM）TSA 和 500 μM（不是 200 nM）VPA。更正后的句子如下。上页。 3531：为了测试出生后下调期间 Atoh1 组蛋白脱乙酰化的要求，我们用 500 μM 丙戊酸 (VPA)（一种广谱组蛋白脱乙酰酶抑制剂 (HDACi)）处理 P1 器官培养物 6 或 24 小时（Göttlicher 等，2001）（图 3C）。上页。 3534：胚胎耳蜗培养物直接放入药物/载体中；产后培养物恢复 2-3 小时，然后给予药物 [30 μM 姜黄素 (Enzo Life Sci, ALX-350-M010)、250 μMBA (Enzo Life Sci, ALX-778-649-18-6)、200 nM TSA (Sigma) 和 500 μM VPA (Sigma)]。作者为这个错误向读者致歉。
There was an error published in Development 142, 3529-3536. The concentrations of two drugs were wrongly reported. The correct values are 200 nM (not 500 μM) TSA and 500 μM (not 200 nM) VPA. Corrected sentences read as follows. On p. 3531: To test the requirement for histone deacetylation of Atoh1 during postnatal downregulation, we treated P1 organ cultures for 6 or 24 h with 500 μM valproic acid (VPA), a broad-spectrum histone deacetylase inhibitor (HDACi) (Göttlicher et al., 2001) (Fig. 3C). On p. 3534: Embryonic cochlear cultures were placed directly in the drug/vehicle; postnatal cultures were allowed to recover for 2-3 hours before administering the drugs [30 μM curcumin (Enzo Life Sci, ALX-350-M010), 250 μMBA (Enzo Life Sci, ALX-778-649-18-6), 200 nM TSA (Sigma) and 500 μM VPA (Sigma)]. The authors apologise to readers for this mistake.