Morphogenesis of the Skin
Morphogenesis of the Skin
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皮肤的形态发生
DOI：
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发表时间：
1977
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通讯作者：
J. Nordlund
中科院分区：
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作者：
J. Nordlund
这本由Phillippe Sengel撰写的优秀专著汇集了大量关于哺乳动物、鸟类和爬行动物皮肤胚胎发育的数据，以及有关产生这些变化的许多化学因素和组织相互作用的大多数可用信息。这本书分为四个部分。第一个描述了发育中的皮肤的组织发生，用光学或电子显微镜可以看到。除了对表皮的讨论外，还提供了大量关于真皮、毛发和羽毛的组织发生的信息。第二部分汇编了关于表皮细胞增殖的数据；许多细胞分裂的化学调节剂，如查尔酮、前列腺素和表皮生长因子；以及表皮-真皮相互作用对基底细胞有丝分裂的影响。这一部分以关于细胞增殖与地形的关系以及表皮、毛发和羽毛的结构的极好的讨论结束。第三部分介绍了表皮内细胞分化的组织学特征以及已发现的细胞分化调节因子，如真皮-表皮相互作用、维生素A和氢化可的松。第四节综合这些数据，以显示这两个过程--细胞增殖和分化--结合形成最终产品的机制，即新生儿的皮肤。关于毛发和羽毛的形态发生的介绍，作者的特长，特别完整和做得好。这本书在大多数方面都很优秀。作者特别值得赞扬，因为他包括了关于真皮的发育和形成的部分，真皮是皮肤中被遗忘的一部分。作者是该领域的专家，能够以清晰、简洁的方式提供广泛的数据。这本书将对发育生物学家和皮肤科医生，或对角质形成细胞和角质化的疾病，如牛皮癣或鱼鳞病，影响真皮-表皮相互作用的疾病，如大疱性表皮松解症，或头发形成，如念珠菌的特别感兴趣的其他内科医生最有价值。对这本书的唯一有效批评应该针对出版商。作者汇编了1973年以前皮肤发育的数据。1974年5月，他完成了对这本专著的介绍，并注明了日期，但这本书直到1975年底才出版，几乎推迟了两年，在此期间，有了大量的新数据。尽管有这样的批评，但对于那些寻求关于皮肤形态发生的详细信息的人来说，这本书是值得的。耶鲁大学医学院皮肤科
This excellent monograph by Phillippe Sengel brings together an enormous body of data on the embryonic development of the skin in mammals, birds, and reptiles, and most of the information available on the many chemical factors and tissue interactions which produce these changes. The book is divided into four sections. The first describes the histogenesis of developing skin visible with the light or electron microscope. In addition to the discussion on epidermis, a substantial amount of information is presented about the histogenesis of the dermis, hair and feathers. The second section compiles the data on proliferation of the epidermal cells; the many chemical regulators of cellular division such as chalones, prostaglandins, and epidermal growth factor; and the effect of epidermal-dermal interaction on basal cell mitosis. The section concludes with a superb discussion on the relationship of cellular proliferation to topography, and architecture of the epidermis, hair and feathers. The third part presents the histologic features of cellular differentiation within the epidermis and the identified regulators of cellular differentiation such as dermalepidermal interactions, vitamin A and hydrocortisone. Section four synthesizes the data to show the mechanisms by which these two processes, cellular proliferation and differentiation, combine to form the final product, i.e., the skin of the neonate. The presentation on morphogenesis of the hair and feathers, the author's specialties, are especially complete and well done. The book is excellent in most respects. The author deserves special credit for including sections on the development and formation of the dermis, a forgotten portion of the skin. The author is an expert in the field and is able to present a wide range of data in clear, concise fashion. The book will be of most value to developmental biologists and dermatologists, or other physicians with a particular interest in diseases of keratinocytes and keratinization such as psoriasis or ichthyosis; diseases affecting dermal-epidermal interaction such as epidermolysis bullosa; or hair formation such as monilethrix. The single valid criticism of the book should be directed at the publisher. The author compiled the data on development of the skin up to 1973. He completed and dated his introduction to the monograph in May 1974, but the book was not published until late 1975, almost two years' delay during which time substantial amounts of new data became available. Despite this criticism, the book is worth obtaining for those seeking detailed information on the morphogenesis of the skin. JAMES J. NORDLUND Department of Dermatology Yale University School of Medicine