Prion protein released by platelets.
Prion protein released by platelets.
复制标题
血小板释放的朊病毒蛋白。
DOI：
10.1016/s0140-6736(96)91128-9
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Prelli,F
中科院分区：
文献类型：
--
作者：
Perini,F;Frangione,B;Prelli,F
由于血小板在其表面上表达Prpc，因此它们可以构成用于通过病理性Prpsc转化正常Prpc的基质，并且可以是这些改变的蛋白质通过身体的可能载体。另一方面，血小板脱落正常可溶性PrP同种型的事实是重要的，因为淀粉样蛋白，如阿尔茨海默病，被认为是来源于存在于生物流体中的可溶性前体或其片段，其在疾病状态下经历构象变化，导致聚集和沉积在靶组织中。此外，血小板中正常可溶性朊病毒蛋白的存在可能允许解决关于朊病毒疾病中Prpc转化为PrPs°的功能、机制和淀粉样蛋白生成的重要问题。
Because platelets express Prpc on their surface, they may constitute a matrix for the conversion of the normal Prpc by the pathological Prpsc and may be a possible carrier of these altered proteins through the body. On the other hand, the fact that platelets shed normal soluble PrP isoforms is important because amyloid proteins, as in Alzheimer’s disease, are thought to derive from soluble precursors or fragments thereof present in biological fluids, which in the disease state undergo conformational change leading to aggregation and deposition in target tissues.’’Furthermore the presence of the normal, soluble prion protein in platelets may allow important questions regarding the functions, the mechanism of Prpc transformation to PrPs°, and amyloidogenesis in prion diseases to be addressed.