Deficiencies in addressing effect modification in network meta-analyses: a meta-epidemiological survey
Deficiencies in addressing effect modification in network meta-analyses: a meta-epidemiological survey
复制标题
DOI：
10.1016/j.jclinepi.2017.06.004
复制
发表时间：
2017-08-01
影响因子：
7.2
通讯作者：
Thabane, Lehana
中科院分区：
文献类型：
--
作者：
Kovic, Bruno;Zoratti, Michael J.;Thabane, Lehana
目的：本研究的目的是评估网络meta分析（nma）中效果修饰的报告和处理的现状，并进行探索性分析，以确定可能与nma中效果修饰不完整报告相关的变量。研究设计和背景：我们对2013年发表的nma进行了meta流行病学调查，并通过MEDLINE和Embase数据库进行了识别。结果：本综述共鉴定出77个nma。发现和探讨的最常见的效应调节因子类型是患者特征（50.7%或39/77），最常用的调节方法是敏感性分析（51.7%或30/58）。超过45%（35/77）的研究没有描述计划，近40%（30/77）的研究没有报告分析结果，约47%（36/77）的研究报告不完整。探索性单变量回归分析显示，期刊影响因子、随机对照试验数与比较数之比、随机对照试验总数等变量之间存在统计学显著相关性。结论：目前的报告实践在很大程度上是有缺陷的，因为几乎一半已确定的nma没有探索或报告效果修改。期刊影响因子和网络中可用信息的数量与报告的完整性有关。(C) 2017爱思唯尔公司版权所有。
Objective: The objectives of this study were to evaluate the current state of reporting and handling of effect modification in network meta-analyses (NMAs) and perform exploratory analyses to identify variables that are potentially associated with incomplete reporting of effect modifiers in NMAs.Study Design and Setting: We conducted a meta-epidemiological survey using a systematic review of NMAs published in 2013 and identified through MEDLINE and Embase databases.Results: The review identified 77 NMAs. The most common type of effect modifiers identified and explored were patient characteristics (50.7% or 39/77), and the most common adjustment method used was sensitivity analysis (51.7% or 30/58). Over 45% (35/77) of studies did not describe a plan, nearly 40% (30/77) did not report the results of analyses, and approximately 47% (36/77) of studies had incomplete reporting. Exploratory univariate regression analyses yielded a statistically significant association for the variables of journal impact factor, ratio of randomized controlled trials to number of comparisons, and total number of randomized controlled trials.Conclusion: Current reporting practices are largely deficient, given that almost half of identified published NMAs do not explore or report effect modification. Journal impact factor and amount of available information in a network were associated with completeness of reporting. (C) 2017 Elsevier Inc. All rights reserved.