Computational analysis of primary implant stability in trabecular bone
Computational analysis of primary implant stability in trabecular bone
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DOI：
10.1016/j.jbiomech.2014.12.008
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发表时间：
2015-03-18
影响因子：
2.4
通讯作者：
van Lenthe, G. Harry
中科院分区：
文献类型：
--
作者：
Steiner, Juri A.;Ferguson, Stephen J.;van Lenthe, G. Harry
骨折骨质疏松性骨的安全固定是一个严重的临床挑战，主要是因为低密度骨的机械性能降低阻碍了正确的内固定。最近的实验结果显示了一个相当复杂的骨-种植体界面接触的有力证据。行为，具有摩擦和非线性力学性能。此外，即使在特定个体的同一解剖部位，骨微结构也是高度多样化的。由于这种内在的可变性，可以详细分析螺钉设计和螺纹几何形状的实验研究将需要非常大量的骨标本；这阻碍了对植入物固定的潜在改进。作为一种补充方法，计算方法可以克服这一限制，因为相同的试样可以在多种配置和各种加载条件下重复测试。成像技术的最新进展与并行计算方法相结合，使得能够非常详细地表示骨植入系统的高分辨率有限元模型的创建成为可能。然而，无论是在表观水平还是在局部微观结构水平上，骨种植体系统力学能力的预测能力仍然有限。目前在高分辨率有限元模型中模拟骨-种植体界面的策略，采用全键的立方体元素，需要重新考虑，改进和验证，以便它更接近地模拟体外观察到的实际非线性力学行为，以便充分利用数值模型的潜力，作为物理体外模型的有效补充研究方法。(C) 2014 Elsevier Ltd.版权所有。
Secure fixation of fractured osteoporotic bone is a serious clinical challenge mainly because the reduced mechanical competence of low-density bone hampers proper implant fixation. Recent experimental findings have shown strong evidence for a rather complex bone-implant interface contact.behavior, with frictional and non-linear mechanical properties. Furthermore, the bone microarchitecture is highly diverse even within the same anatomical site of a specific individual. Due to this intrinsic variability experimental studies that could analyze in detail the contributions of screw designs and thread geometry would require a very large amount of bone specimens; this hampers finding potential improvements for implant fixation. As a complementary approach, computational methods may overcome this limitation, since the same specimen can be tested repeatedly in numerous configurations and under various loading conditions. Recent advances in imaging techniques combined with parallel computing methods have enabled the creation of high-resolution finite-element models that are able to represent bone-implant systems in great detail. Yet, the predictive power of the mechanical competence of bone-implant systems is still limited, both on the apparent level and on the local microstructural level. The current strategy in high-resolution FE models to model the bone-implant interface, employing fully bonded cube-like elements, needs to be reconsidered, refined and validated, such that it mimics more closely the actual non-linear mechanical behavior as observed in vitro in order to exploit the full potential of numeric models as an effective, complementary research method to physical in vitro models. (C) 2014 Elsevier Ltd. All rights reserved.