ŒSTROGEN RECEPTORS IN HUMAN MALIGNANT MELANOMA
ŒSTROGEN RECEPTORS IN HUMAN MALIGNANT MELANOMA
复制标题
人类恶性黑色素瘤中的雌激素受体
DOI：
10.1016/s0140-6736(76)92592-7
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
M. Lippman
中科院分区：
文献类型：
--
作者：
R. Fisher;J. Neifeld;M. Lippman
35例恶性黑色素瘤患者中有16例（46%）在活检标本中发现细胞质œstrogen-receptor活性。在原发性病变、淋巴结转移、皮肤转移和内脏转移中检测到Œtrogen-receptor活性。男性和女性的阳性检测比例相同。其中一例的Scatchard结合分析与一类高亲和受体位点一致。
16 of 35 patients (46%) with malignant melanoma were found to have cytoplasmic œstrogen-receptor activity in biopsy specimens. Œtrogen-receptor activity was detected in primary lesions, lymph-node metastases, skin metastases, and visceral metastases. Equal percentages of males and females had positive assays. Scatchard analysis of binding in one case was consistent with a single class of high-affinity receptor sites.