Phase synchrony among neuronal oscillations in the human cortex
Phase synchrony among neuronal oscillations in the human cortex
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DOI：
10.1523/jneurosci.4250-04.2005
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发表时间：
2005-04-13
影响因子：
5.3
通讯作者：
Kaila, K
中科院分区：
文献类型：
--
作者：
Palva, JM;Palva, S;Kaila, K
神经元活动的同步通常与网络振荡相关，被认为提供了一种在大脑中整合解剖分布处理的方法。然而，神经元处理涉及不同频段的同时振荡。这种光谱分布处理的整合所涉及的机制仍然是个谜。我们使用脑磁图证明，在频率从 3 到 80 Hz 的振荡中，人类皮层中存在鲁棒的跨频相位同步。连续的心算任务需要对工作记忆中的项目进行保留和求和，从而增强了 α（类似于 10 Hz）、β（类似于 20 Hz）和伽玛（类似于 30-40 Hz）振荡之间的跨频相位同步性。这些任务还增强了这些频段中的“经典”频内同步，但 alpha、beta 和 gamma 同步的空间模式是不同的，而且与跨频相位同步的模式是分开的。有趣的是，任务负载的增加导致了相位同步的增强，这在伽马和阿尔法波段振荡之间最为突出。这些数据表明，跨频相位同步是人类皮层正在进行的活动的显着特征，并且它受到认知任务需求的调节。在心算任务期间，功能和空间不同的网络之间跨频相位同步的增强使其成为频谱分布式处理集成的候选机制。
Synchronization of neuronal activity, often associated with network oscillations, is thought to provide a means for integrating anatomically distributed processing in the brain. Neuronal processing, however, involves simultaneous oscillations in various frequency bands. The mechanisms involved in the integration of such spectrally distributed processing have remained enigmatic. We demonstrate, using magnetoencephalography, that robust cross-frequency phase synchrony is present in the human cortex among oscillations with frequencies from 3 to 80 Hz. Continuous mental arithmetic tasks demanding the retention and summation of items in the working memory enhanced the cross-frequency phase synchrony among alpha (similar to 10 Hz), beta (similar to 20 Hz), and gamma (similar to 30-40 Hz) oscillations. These tasks also enhanced the "classical" within-frequency synchrony in these frequency bands, but the spatial patterns of alpha, beta, and gamma synchronies were distinct and, furthermore, separate from the patterns of cross-frequency phase synchrony. Interestingly, an increase in task load resulted in an enhancement of phase synchrony that was most prominent between gamma- and alpha-band oscillations. These data indicate that cross-frequency phase synchrony is a salient characteristic of ongoing activity in the human cortex and that it is modulated by cognitive task demands. The enhancement of cross-frequency phase synchrony among functionally and spatially distinct networks during mental arithmetic tasks posits it as a candidate mechanism for the integration of spectrally distributed processing.