Association of hypertriglyceridemic-waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN-III study
Association of hypertriglyceridemic-waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN-III study
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DOI：
10.1016/j.jped.2015.12.009
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发表时间：
2016-10-01
影响因子：
3.3
通讯作者：
Hovsepian, Silva
中科院分区：
文献类型：
--
作者：
Kelishadi, Roya;Jamshidi, Fahimeh;Hovsepian, Silva
目的：本研究旨在调查伊朗儿童全国样本中代谢综合征（MetS）和高甘油三酯血症（HW）表型在确定心脏代谢危险因素和肝酶升高中的作用。方法：这项全国性研究是在监测计划第三次调查的框架内进行的。来自伊朗27个省份的10-18岁学生。比较了有和没有 HW 和 MetS 的学生的心脏代谢危险因素的患病率。确定了 NW 与不同心脏代谢危险因素的关联。结果：研究人群的平均年龄为 14.73 +/- 2.41 岁。 HW 和 MetS 的患病率分别为 3.3% 和 4%。 69 名 (71.1%) 患有 HW 的参与者患有 MetS。具有 NW 表型和 MetS 的受试者中肥胖、收缩压升高、高胆固醇血症和丙氨酸转氨酶 (ALT) 升高的患病率显着高于同龄人 (p < 0.05)。 HW 与胆固醇和 ALT 水平升高之间以及肥胖与低 HDL-C 之间存在显着相关性 (p < 0.05)。结论：当前的研究结果是对之前主要在成人中进行的研究的补充证据，表明 HW 表型与心脏代谢危险因素相关，尤其是与胆固醇和 ALT 升高相关。作者提出，在初级保健机构和大型流行病学研究中，所有 MetS 成分的测量可以通过研究 HW 来替代，作为识别心脏代谢疾病高风险儿童的筛查工具。 (C) 2016 年由 Elsevier Editora Ltda 出版。代表巴西儿科协会。
Objective: This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic-waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population.Method: This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10-18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of NW with different cardiometabolic risk factors was determined.Results: The mean age of studied population was 14.73 +/- 2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty-nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated alanine aminotransaminase (ALT) was significantly higher in subjects with NW phenotype and MetS than in their peers (p < 0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL-C (p < 0.05).Conclusions: The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders. (C) 2016 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.