Microfluidic Synthesis of Elastomeric Microparticles: A Case Study in Catalysis of Palladium-Mediated Cross-Coupling
Microfluidic Synthesis of Elastomeric Microparticles: A Case Study in Catalysis of Palladium-Mediated Cross-Coupling
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DOI：
10.1002/aic.16119
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发表时间：
2018-08-01
期刊：
影响因子：
3.7
通讯作者：
Abolhasani, Milad
中科院分区：
文献类型：
--
作者：
Bennett, Jeffrey A.;Kristof, Andrew J.;Abolhasani, Milad
在一个使用现成组件构建的基于毛细管的同轴流聚焦微流控装置中，制备了尺寸和弹性可调的载钯（Pd）聚氢甲基硅氧烷（PHMS）微粒。通过调节微反应器环形流中交联催化剂的稀释度，同时进行液滴形成和化学交联过程，从而一步合成PHMS微粒。弹性体微粒的大小可通过调节聚合物和交联剂混合物与水的流速比来调节，而弹性可通过聚合物与交联剂的比例以及聚合物混合物与交联催化剂混合物的流速比来调节。微粒的弹性通过溶剂吸收程度来表征。通过制备单分散的载钯微粒，并将其用作微反应容器，在载钯微粒填充床反应器中进行连续的铃木 - 宫浦交叉偶联反应，展示了所合成的PHMS微粒在有机合成中的应用。（C）2018美国化学工程师学会
Palladium (Pd)-loaded poly-hydromethylsiloxane (PHMS) microparticles of tunable size and elasticity are prepared in a capillary-based coaxial flow-focusing microfluidic device constructed using off-the-shelf components. Simultaneous droplet formation and chemical cross-linking processes are performed by tuning the dilution of the cross-linking catalyst in the annular flow of the microreactor, resulting in PHMS microparticles synthesized in a single step. The size of the elastomeric microparticles can be tuned by adjusting the flow rate ratio of the polymer and cross-linker mixture to water, while the elasticity can be tuned by the polymer to cross-linker ratio as well as the flow rate ratio of the polymer mixture to cross-linking catalyst mixture. Microparticle elasticity is characterized by the degree of solvent uptake. Application of the synthesized PHMS microparticles in organic synthesis is demonstrated by producing monodispersed Pd-loaded microparticles and utilizing them as microreaction vessels for continuous Suzuki-Miyaura cross-coupling in a Pd-loaded microparticle-packed bed reactor. (C) 2018 American Institute of Chemical Engineers