The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia
The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia
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DOI：
10.1007/s10552-009-9433-9
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发表时间：
2010-01-01
影响因子：
2.3
通讯作者：
Kim, Mi Kyung
中科院分区：
文献类型：
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作者：
Hwang, Jong Ha;Lee, Jae Kwan;Kim, Mi Kyung
我们评估了蔬菜和水果的饮食摄入量与宫颈上皮内瘤变（CIN）风险之间的关系，并确定这些相关性是否受到人乳头瘤病毒（HPV）病毒载量的影响。从2006年3月至今，我们招募了1,096名年龄在18-65岁之间的女性参加HPV队列研究。在这项分析中，我们纳入了328名HPV阳性女性（166名对照，90名CIN I和72名CIN II/III）。采用多项logistic方法估计多变量比值比（OR）和相应的95%置信区间（CI）。在控制了潜在的混杂因素后，我们发现HPV病毒载量较高与CIN I（OR = 2.68，95%CI，1.19-6.04）和CIN II/III（OR = 2.78，95%CI，1.15-6.72）的风险增加相关。HPV感染、蔬菜水果摄入量与宫颈上皮内瘤变的关系无统计学意义。然而，蔬菜和水果摄入量较低，病毒载量较高的受试者（千分之15.5）CIN II/III的风险较高（OR = 2.84（1.26-6.42），交互作用p = 0.06; OR = 2.93（1.25-6.87），水果交互作用p = 0.01），与蔬菜和水果摄入量较低，病毒载量较低（< 15.5）的受试者相比。我们的研究结果表明，蔬菜和水果的饮食摄入量与宫颈癌的进展有关。
We evaluated the relationship between the dietary intake of vegetables and fruits, and the risk of cervical intraepithelial neoplasia (CIN) and determined whether these associations were modified by human papillomavirus (HPV) viral load. We enrolled 1,096 women aged 18-65 to participate in a HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls, 90 CIN I and 72 CIN II/III). The multivariate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated by multinomial logistic methods. After controlling for potential confounders, we found that a higher HPV viral load was associated with an increased risk of CIN I (OR = 2.68, 95% CI, 1.19-6.04) and CIN II/III (OR = 2.78, 95% CI, 1.15-6.72). The relationships between HPV infection, dietary intake of vegetables and fruits and risk of CIN were not statistically significant. However, subjects with lower intake of vegetables and fruits, and a higher viral load (a parts per thousand yen15.5) have a higher risk of CIN II/III (OR = 2.84(1.26-6.42), interaction p = 0.06 for vegetables; OR = 2.93(1.25-6.87), interaction p = 0.01 for fruits), compared with subjects with lower intake of vegetables and fruits, and a lower viral load (< 15.5). Our findings suggest that the dietary intake of vegetables and fruits is associated with the progression of cervical carcinogenesis.