Polymorphonuclear myeloid-derived suppressor cells attenuate allergic airway inflammation by negatively regulating group 2 innate lymphoid cells
Polymorphonuclear myeloid-derived suppressor cells attenuate allergic airway inflammation by negatively regulating group 2 innate lymphoid cells
复制标题
多形核骨髓源性抑制细胞通过负调节第 2 组先天淋巴细胞减轻过敏性气道炎症
DOI：
10.1111/imm.13040
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发表时间：
2019-04-01
期刊：
影响因子：
6.4
通讯作者：
Zhou, Jie
中科院分区：
文献类型：
--
作者：
Cao, Yingjiao;He, Yumei;Zhou, Jie
2型免疫反应过度激活是过敏性哮喘的主要发病机制，2型固有淋巴样细胞(ILC2s)和2型辅助性T细胞(Th2)均参与其中。髓系抑制细胞(MDSCs)通过抑制Th2细胞来缓解哮喘。然而，MDSCs对ILC2生物学功能的潜在影响在很大程度上仍不清楚。在这里，我们研究了MDSCs(MDSCs)在ILC2功能调节中的作用。我们的结果显示，中性粒细胞(PMN)-MDSCs，而不是单核(M-)MDSCs，在体外和体内都能有效地抑制ILC2s细胞因子的产生，从而减轻呼吸道炎症。进一步分析表明，环氧合酶-1可能介导了PMN-MDSCs对ILC2反应的抑制作用。我们的研究结果表明，PMN-MDSCs可能成为ILC2驱动的过敏性哮喘的有效治疗靶点。
Hyperactivation of the type 2 immune response is the major mechanism of allergic asthma, in which both group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells participate. Myeloid-derived suppressor cells (MDSCs) alleviate asthma by suppressing Th2 cells. However, the potential effects of MDSCs on the biological functions of ILC2s remain largely unknown. Here, we examined the roles of MDSCs (MDSCs) in the modulation of ILC2 function. Our results showed that polymorphonuclear (PMN)-MDSCs, but not monocytic (M-) MDSCs, effectively suppressed the cytokine production of ILC2s both invitro and invivo, thereby alleviating airway inflammation. Further analyses showed that cyclo-oxygenase-1 may mediate the suppressive effects of PMN-MDSCs on ILC2 responses. Our findings demonstrated that PMN-MDSCs may serve as a potent therapeutic target for the treatment of ILC2-driven allergic asthma.