Testosterone stimulation of the medial preoptic area and medial amygdala in the control of male hamster sexual behavior: redundancy without amplification.
Testosterone stimulation of the medial preoptic area and medial amygdala in the control of male hamster sexual behavior: redundancy without amplification.
复制标题
睾酮刺激内侧视前区和内侧杏仁核控制雄性仓鼠性行为：冗余而不放大。
DOI：
10.1016/s0166-4328(98)00063-1
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发表时间：
1999
影响因子：
2.7
通讯作者：
Wood,RI
中科院分区：
文献类型：
--
作者：
Coolen,LM;Wood,RI
性腺类固醇受体存在于边缘核相互连接的网络中。这种网络结构的存在对类固醇如何控制生殖生理和行为具有重要的意义。1986年，Cottingham和Pfaff提出类固醇反应神经网络的性质可以包括冗余、放大、稳定性和选择性过滤。本研究以雄性仓鼠性行为为模型，对类固醇放大的概念进行了检验。在雄性仓鼠中，杏仁内侧核(Me)和内侧视前区(MPOA)对交配行为是必不可少的，这两个核团都传递类固醇信号以促进交配。为了确定类固醇在多个相互连接的核团中的作用是否会增强交配，本研究比较了在Me或MPOA中植入单侧睾酮的去势雄性仓鼠与在Me和MPOA中植入双重睾酮的雄性仓鼠的性行为。刺激Me或MPOA中含有雄激素受体的神经元的植入刺激了高于去势水平的交配行为。然而，双种植体男性的行为与单种植体男性的行为没有显著差异。这表明，类固醇对MPOA或Me的作用足以促进交配，但对这些相互关联的核的双重刺激不会放大性行为。
Receptors for gonadal steroids are present in an interconnected network of limbic nuclei. The existence of this network structure has important implications for how steroids control reproductive physiology and behavior. In 1986, Cottingham and Pfaff proposed that properties of a steroid-responsive neural network could include redundancy, amplification, stability and selective filtering. The present study tested the concept of steroid amplification, using male hamster sexual behavior as a model. In the male hamster, the medial amygdaloid nucleus (Me) and medial preoptic area (MPOA) are essential for mating behavior, and both nuclei transduce steroid cues to facilitate copulation. To determine if steroid action at multiple interconnected nuclei amplifies mating, the present study compared sexual behavior in castrated male hamsters bearing unilateral intracranial implants of testosterone in Me or MPOA with that of males with dual testosterone implants in Me and MPOA. Implants that stimulated androgen receptor-containing neurons in Me or MPOA stimulated copulatory behavior above castrate levels. However, behavior of males with dual implants was not significantly different from that of males with single implants. This suggests that steroid action at either MPOA or Me is sufficient to facilitate mating, but dual stimulation of these reciprocally-connected nuclei does not amplify sexual behavior.