Intestinal epithelial TOLLerance versus inTOLLerance of commensals
Intestinal epithelial TOLLerance versus inTOLLerance of commensals
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DOI：
10.1016/j.molimm.2004.12.002
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发表时间：
2005-05-01
影响因子：
3.6
通讯作者：
Podolsky, DK
中科院分区：
文献类型：
--
作者：
Cario, E;Podolsky, DK
这篇简短的综述总结了目前对 Toll 样受体 (TLR) 介导的共生耐受与不耐受的肠上皮机制的理解，并提供了通过减少表面表达、与 NOD2 相互调节、Tollip 过度表达、各种 NF-κ B 抑制剂以及管腔和血清中存在的可溶性耐受介质对信号反应进行下游负控制的最新信息，这些介质都可能维持或当失调时损害粘膜分别是健康或疾病的稳态。 (c) 2004 Elsevier Ltd. 保留所有权利。
This brief review summarizes the current understanding of Toll-like receptor (TLRs) mediated intestinal epithelial mechanisins of commensal tolerance versus intolerance and provides an update on the downstream ne,gative control of signaling responses through decreased surface expression, interregulation with NOD2, overexpression of Tollip, various inhibitors of NF-kappa B as well as Soluble tolerizing mediators present in lumen and serum which all may maintain or-when dysregulated-impair mucosal homeostasis in health or disease, respectively. (c) 2004 Elsevier Ltd. All rights reserved.