Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
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DOI：
10.1371/journal.pone.0029635
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Mueller K
中科院分区：
文献类型：
--
作者：
Dušek P;Jech R;Sieger T;Vymazal J;Růžička E;Wackermann J;Mueller K
帕金森病（PD）患者缺乏时间估计能力。这种缺陷在多巴胺（DA）治疗后得到改善，并且与内部计时速度降低、执行功能破坏和记忆检索功能障碍有关。本研究的目的是探讨这种缺陷的神经生理学相关性。我们对 12 名 PD 患者进行了功能性磁共振成像，同时他们正在执行时间再现任务 (TRT)。 TRT 包括编码阶段（在此期间呈现持续时间从 5 秒到 16.6 秒、以 8 个级别变化的视觉刺激）和再现阶段（在此期间通过按下按钮来再现间隔持续时间）。患者接受了两次扫描，一次是在服用 DA 药物期间（ON 条件），一次是在停药后（OFF 条件）。评估了开启和关闭条件下血氧水平依赖性 (BOLD) 信号的差异。绘制了具有不同 BOLD 信号的大脑区域激活的时间过程。行为结果没有显着差异，但在关闭条件下有高估间隔≤11.9s和低估间隔≥14.1s的趋势（p<0.088）。在繁殖阶段，在 ON 条件下发现楔前叶有较高的激活（p<0.05 校正）。分别绘制长间隔（≥14.1s）和短间隔（≤11.9s）的时间进程。结果显示，仅在长间隔时存在显着差异，此时活性在关闭状态下逐渐下降，但在开启状态下保持稳定。在控制任务中随机按下按钮时，未发现楔前叶激活的差异。我们的结果表明，在检索记忆持续时间过程中楔前叶激活的差异可能是帕金森病患者时间知觉缺陷某些方面的基础。我们建议 DA 药物可能允许楔前叶代偿性激活，从而更准确地检索记忆的间隔持续时间。
Parkinson's disease (PD) patients are deficient in time estimation. This deficit improves after dopamine (DA) treatment and it has been associated with decreased internal timekeeper speed, disruption of executive function and memory retrieval dysfunction. The aim of the present study was to explore the neurophysiologic correlates of this deficit. We performed functional magnetic resonance imaging on twelve PD patients while they were performing a time reproduction task (TRT). The TRT consisted of an encoding phase (during which visual stimuli of durations from 5s to 16.6s, varied at 8 levels were presented) and a reproduction phase (during which interval durations were reproduced by a button pressing). Patients were scanned twice, once while on their DA medication (ON condition) and once after medication withdrawal (OFF condition). Differences in Blood-Oxygenation-Level-Dependent (BOLD) signal in ON and OFF conditions were evaluated. The time course of activation in the brain areas with different BOLD signal was plotted. There were no significant differences in the behavioral results, but a trend toward overestimation of intervals ≤11.9s and underestimation of intervals ≥14.1s in the OFF condition (p<0.088). During the reproduction phase, higher activation in the precuneus was found in the ON condition (p<0.05 corrected). Time course was plotted separately for long (≥14.1s) and short (≤11.9s) intervals. Results showed that there was a significant difference only in long intervals, when activity gradually decreased in the OFF, but remained stable in the ON condition. This difference in precuneus activation was not found during random button presses in a control task. Our results show that differences in precuneus activation during retrieval of a remembered duration may underlie some aspects of time perception deficit in PD patients. We suggest that DA medication may allow compensatory activation in the precuneus, which results in a more accurate retrieval of remembered interval duration.
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