SPATIAL, MOVEMENT-SENSITIVE AND REWARD-SENSITIVE DISCHARGE BY MEDIAL VENTRAL STRIATUM NEURONS OF RATS
SPATIAL, MOVEMENT-SENSITIVE AND REWARD-SENSITIVE DISCHARGE BY MEDIAL VENTRAL STRIATUM NEURONS OF RATS
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DOI：
10.1016/0006-8993(94)90645-9
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发表时间：
1994-02-28
期刊：
影响因子：
2.9
通讯作者：
MIZUMORI, SJY
中科院分区：
文献类型：
--
作者：
LAVOIE, AM;MIZUMORI, SJY
先前的行为和急性电生理数据使研究人员推测，丘脑核整合了边缘系统、奖励和运动信息[5，12，22，31]。本研究探讨了行为相关的单个单位活动的核腹侧纹状体和周围作为一种手段，评估该地区在清醒的动物的综合功能。当大鼠在八臂径向迷宫上完成多次试验时，记录内侧腹侧纹状体（mVS）活动。神经元活动被发现与空间，奖励和运动相关的行为条件。虽然大多数细胞表现出单一类型的相关性（即空间或奖励相关性），但6个细胞编码不同类型的多个相关性（即空间和奖励相关性），数据表明这种整合过程可以在单个神经元水平和结构水平上都是活跃的。这些结果与mVS整合空间和奖励相关信息的假设是一致的，这反过来又会影响自愿运动输出结构，以实现准确的导航行为。
Previous behavioral and acute electrophysiological data have lead researchers to speculate that the nucleus accumbens integrates limbic, reward and motor information [5,12,22,31]. The present study examined the behavioral correlates to single unit activity of the nucleus accumbens and surrounding ventral striatum as a means of evaluating the integrative functioning of this region in an awake animal. Medial ventral striatum (mVS) activity was recorded as rats completed multiple trials on an eight arm radial maze. Neuronal activity was found to correlate with spatial, reward- and movement-related behavioral conditions. While the majority of cells demonstrated correlates of a single type (i.e. either spatial or reward correlates), 6 cells encoded multiple correlates of different types (i.e. spatial and reward correlates), The data suggests that this integrative process can be active both at the level of the individual neuron, and at the structural level. These results are consistent with the hypothesis that the mVS integrates spatial and reward-related information, which in turn influences voluntary motor output structures in order to achieve accurate navigational behavior.