Cutaneous nociception: Role of keratinocytes

Cutaneous nociception: Role of keratinocytes
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皮肤伤害感受:角质形成细胞的作用

DOI:
10.1111/exd.13975
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发表时间:
2019
影响因子:
3.6
通讯作者:
L. Miséry
L. Miséry
中科院分区:
医学2区
文献类型:
--
作者:
M. Talagas;N. Lebonvallet;F. Berthod;L. Miséry

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近年来,角质形成细胞对皮肤伤害性感受的作用得到了进一步的了解。虽然传统上认为表皮内神经末梢是皮肤伤害性刺激的唯一转导器,但现在已经证明表皮角质形成细胞可以启动伤害性反应,就像默克尔细胞对无害的机械转导所做的那样。根据最近的体内研究结果,本文概述了这种范式的转变,指向一个尚未考虑的人口的感觉表皮细胞。
Recent years have brought an enhanced understanding of keratinocyte contribution to cutaneous nociception. While intra‐epidermal nerve endings were classically considered as the exclusive transducers of cutaneous noxious stimuli, it has now been demonstrated that epidermal keratinocytes can initiate nociceptive responses, like Merkel cells do for the innocuous mechanotransduction. In the light of recent in vivo findings, this article outlines this paradigm shift that points to a not yet considered population of sensory epidermal cells.
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