Laser-evoked potentials in human pain - I. Use and possible misuse
Laser-evoked potentials in human pain - I. Use and possible misuse
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DOI：
10.1016/s1082-3174(98)70001-7
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发表时间：
1998-12-01
期刊：
影响因子：
--
通讯作者：
Plaghki, L
中科院分区：
文献类型：
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作者：
Chen, ACN;Arendt-Nielsen, L;Plaghki, L
在第一部分中，这篇Focus文章描述了人类疼痛中激光诱发脑电位（LEPs）的特征，并检查了一些方法上的不一致。对警告和支持使用lep的证据进行了对比。许多神经机制清楚地说明了lep和疼痛处理的关系：激光选择性地激发薄传入纤维的皮肤受体、脊髓前外侧束和脑干外侧束。并对其临床应用意义作了简要介绍。我们提出了三个有争议的问题：(1)测量标准；(2)LEP振幅与疼痛的关联和分离；(3)LEP的动态时空特异性。我们的结论是，lep可能反映了伤害性加工，但可能不是整个疼痛体验。我们强调lep在理解疼痛体验中伤害性激活机制中的正确使用。为了实现这一目标，我们解决了研究lep和人类疼痛的动态时空特异性所需的技术进步。
In Part I, this Focus article describes characteristics of laser-evoked brain potentials (LEPs) in human pain and examines some of the methodological inconsistencies. Evidence both cautioning and supporting the use of LEPs is contrasted. A host of neurological mechanisms clearly illustrates the relation of LEPs and pain processing: Lasers elicit selectively the cutaneous receptors of thin afferent fibers, the anterolateral spinal tract, and the lateral tracts of the brainstem. Implication for clinical use is briefly suggested. We raise three contending issues: (1) measurement standard, (2) association and dissociation of the LEP amplitude and pain, and (3) dynamic spatiotemporal specificity of LEPs. We conclude that LEPs may reflect nociceptive processing but may not be the entire pain experience. We emphasize the proper use of LEPs in understanding the mechanisms of nociceptive activation in pain experience. To achieve this, we address the technological advance required in studying the dynamic spatiotemporal specificity of LEPs and human pain.