Differential patterns of extracellular signal-regulated kinase-1 and-2 phosphorylation in rat limbic brain regions after short-term and long-term inhibitory avoidance learning
Differential patterns of extracellular signal-regulated kinase-1 and-2 phosphorylation in rat limbic brain regions after short-term and long-term inhibitory avoidance learning
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DOI：
10.1016/j.neuroscience.2005.10.009
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Wang, CC
中科院分区：
文献类型：
--
作者：
Chai, SC;Holahan, MR;Wang, CC
Activation of the extracellular signal-regulated kinase-11 and -2 has been shown to be required for neural plasticity and memory. Previous pharmacological studies have demonstrated that inhibition of extracellular signal-regulated kinase-1 and -2 blocks inhibitory avoidance retention. The aim of the present study was to investigate the different neural substrates underlying short- and long-term inhibitory avoidance learning and memory in rats using phosphorylated extracellular signal-regulated kinase-1 and -2 labeling as an index of plasticity. Short- and long-term retention tests were given 10 min or 24 h after inhibitory avoidance training. A significant elevation in the number of phosphorylated extracellular signal-regulated kinase-11 and -2-immunoreactive neurons was observed in area 1 of anterior cingulate cortex, the secondary motor cortex, lateral orbital cortex, claustrum, and the medial amygdala nucleus after the short-term inhibitory avoidance test. After the long-term retention test, phosphorylated extracellular signal-regulated kinase-1 and -2-immunoreactive neurons were localized in area 1 of anterior cingulate cortex, prelimbic cortex, and the central nucleus of amygdala. This suggests that phosphorylated extracellular signal-regulated kinase-1 and -2-immunoreactivity may reveal different brain regions involved in the storage of short- and long-term aversive memories. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
