Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein.
Deactivation of visual transduction without guanosine triphosphate hydrolysis by G protein.
复制标题
G 蛋白不经三磷酸鸟苷水解即可使视觉转导失活。
DOI：
10.1126/science.1519062
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Lisman,J
中科院分区：
文献类型：
--
作者：
Erickson,MA;Robinson,P;Lisman,J
G蛋白在许多信号转导级联中将受体偶联到它们的靶酶。一般认为，如果没有G蛋白对鸟苷三磷酸（GTP）的水解，这种级联的失活就不会发生。这一要求现在已经在脊椎动物和无脊椎动物的光转导中被重新研究。结果表明，GTP水解是不需要的失活。证据是一种替代模型，其中目标酶被灭活的抑制因子，即使GTP水解被阻止。
G proteins couple receptors to their target enzymes in many signal transduction cascades. It has generally been thought that deactivation of such cascades cannot occur without the hydrolysis of guanosine triphosphate (GTP) by G protein. This requirement has now been reexamined in both vertebrate and invertebrate phototransduction. Results indicate that GTP hydrolysis is not required for deactivation. Evidence is presented for an alternative model in which the target enzyme is deactivated by an inhibitory factor that is available even when GTP hydrolysis is blocked.