Estradiol-induced changes in rabbit luteal cell progestin production and cholesterol and cholesterol ester content.
Estradiol-induced changes in rabbit luteal cell progestin production and cholesterol and cholesterol ester content.
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雌二醇引起的兔黄体细胞孕激素产生以及胆固醇和胆固醇酯含量的变化。
DOI：
10.1016/0006-291x(83)91101-4
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发表时间：
1983
影响因子：
3.1
通讯作者：
Zirkin,BR
中科院分区：
文献类型：
--
作者：
Holt,JA;Schreiber,JR;Zirkin,BR
体内去势导致假孕兔黄体内胆固醇和胆固醇酯在24小时内蓄积。这些积累伴随着突然停止的resistin生产。用雌二醇再治疗可恢复孕酮的产生，并可阻断胆固醇蓄积的进一步增加（每mg总组织蛋白）。当雌激素缺乏导致雌激素福尔斯下降时，黄体中存在大量的前体胆固醇酯和胆固醇底物。因此，我们得出结论，雌二醇的促性腺作用部分是由于它刺激胆固醇转化为孕激素。
Estradiol deprivation in vivo causes accumulation of cholesterol and cholesterol ester in the corpora lutea of pseudo-pregnant rabbits within 24 hours. These accumulations occur concomitantly with an abrupt cessation of progestin production. Retreatment with estradiol restores progestin production and can block further increases in cholesterol accumulation (per mg total tissue protein). Ample quantities of precursor cholesterol ester and cholesterol substrate are present in corpora lutea when progestin falls because of estradiol deprivation. We conclude therefore that the gonadotropic action of estradiol is, in part, because of its stimulation of cholesterol conversion to progestins.