Effect of serum hyperosmolality on opening of blood-brain barrier for bilirubin in rat brain.
Effect of serum hyperosmolality on opening of blood-brain barrier for bilirubin in rat brain.
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DOI：
10.1542/peds.71.6.909
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发表时间：
1983-06
期刊：
影响因子：
8
通讯作者：
D. Bratlid;W. Cashore;W. Oh
中科院分区：
文献类型：
--
作者：
D. Bratlid;W. Cashore;W. Oh
本文研究了高渗血症对大鼠血脑屏障的影响。通过以30 mg/kg/h的速率输注胆红素3小时，在慢性插管大鼠中诱导高胆红素血症。胆红素输注2小时后，分别以50、75和100 mmol/kg的剂量推注尿素，诱导三种水平的高渗透压。血清渗透压摩尔浓度从对照组的297 mosm/L升高至三个相应组的345、383和400 mosml/L。两组间总胆红素或游离胆红素、血清白蛋白、血液pH值和血气水平无显著差异。脑胆红素和脑白蛋白含量均与血清高渗浓度呈显著剂量关系。结果表明，高渗透压导致开放的血脑屏障胆红素在大鼠。可以推测，这种不良现象（高渗透压）可能在血清胆红素水平低于饱和胆红素结合能力范围的婴儿的核黄疸发病机制中发挥作用。
The effect of hyperosomolality on the blood-brain barrier for bilirubin was studied in rats. Hyperbilirubinemia was induced in the chronically catheterized rat by infusion of bilirubin at a rate of 30 mg/kg/h for three hours. After two hours of bilirubin infusion, three levels of hyperosmolality were induced by bolus of urea at three different doses: 50, 75, and 100 mmol/kg, respectively. The serum osmolality rose from 297 mosm/L in the control group to 345, 383, and 400 mosml/L in the three respective groups. No significant differences were found between the groups in levels of total or free serum bilirubin, serum albumin, blood pH, and blood gases. A significant dose relationship was found in both brain bilirubin and brain albumin content with reference to the serum hyperosmolality. The results indicate that hyperosmolality causes opening of the blood-brain barrier for bilirubin in the rat. It may be speculated that this adverse phenomenon (hyperosmolality) may play a role in the pathogenesis of kernicterus in infants whose serum bilirubin levels are below the range of saturated bilirubin binding capacity.