Neuroendocrine actions and regulation of hypothalamic neuropeptide Y during lactation
Neuroendocrine actions and regulation of hypothalamic neuropeptide Y during lactation
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DOI：
10.1016/j.peptides.2006.09.025
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发表时间：
2007-02-01
期刊：
影响因子：
3
通讯作者：
Kalra, S. P.
中科院分区：
文献类型：
--
作者：
Crowley, W. R.;Ramoz, G.;Kalra, S. P.
在大鼠哺乳期间，下丘脑弓状神经元中神经肽 Y (NPY) 及其共信使刺鼠相关肽 (AgRP) 的表达增加。我们的研究一直在解决这些肽在哺乳期间的生理作用以及与哺乳相关的导致其基因表达增加的生理信号的问题。我们的研究表明，NPY 和 AgRP 在哺乳期间发挥多效作用，有助于将能量平衡的神经内分泌调节与垂体前叶和后叶激素分泌的控制结合起来。此外，瘦素和生长素释放肽向 NPY/AgRP 系统发出的相互信号传导导致哺乳动物中这些下丘脑肽表达的变化，因此可能有助于调节食物摄入和哺乳期的各种神经内分泌适应。 (c) 2007 Elsevier Inc. 保留所有权利。
The expression of neuropeptide Y (NPY) and its co-messenger, agouti-related peptide (AgRP), in arcuate neurons of the hypothalamus is increased during lactation in rats. Our research has been addressing the questions of the physiological actions of these peptides during lactation and the physiological signals associated with lactation that result in increased expression of their genes. Our studies indicate that NPY and AgRP exert pleiotropic actions during lactation that help integrate neuroendocrine regulation of energy balance with controls over anterior and posterior pituitary hormone secretion. Further, reciprocal signaling to the NPY/AgRP system by leptin and ghrelin is responsible for the changes in expression of these hypothalamic peptides in lactating animals, and thus, may contribute to regulation of food intake and the various neuroendocrine adaptations of lactation. (c) 2007 Elsevier Inc. All rights reserved.