A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects.
A comparison of histamine, methacholine, and exercise airway reactivity in normal and asthmatic subjects.
复制标题
正常人和哮喘受试者组胺、乙酰甲胆碱和运动气道反应性的比较。
DOI：
10.1164/arrd.1982.126.2.235
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
P. Norman
中科院分区：
文献类型：
--
作者：
M. Chatham;E. Bleecker;Philip L. Smith;Richard R. Rosenthal;P. Mason;P. Norman
呼吸道反应性通常通过吸入药物如乙酰甲胆碱和组胺或通过运动挑战来评估。为探讨药物激发与运动诱发的支气管收缩的关系，确定最能区分哮喘患者和正常人的试验，对10例正常人和15例哮喘患者进行了研究。通过对8种常见过敏原的一种或多种阳性皮肤试验来确定过敏状态。药理敏感性被定义为引起FEV1下降20%或比电导下降35%的对数剂量的激动剂。在温度为22.3±1.1°C(平均值±标准差)、湿度为40.1±13.3%的条件下，90%的年龄进行6min的稳态跑步机运动，即最大心率。心率(171.5±11.7)、耗氧量(2.19±0.6 5 L/M)、分钟通气量(77.1±2 4.0 L)表现为高度的运动应激。尽管组胺和甲胆碱..。
Airway reactivity is commonly assessed by inhalation exposure to pharmacologic agents such as methacholine and histamine or by exercise challenge. To evaluate the relationship of pharmacologic challenge with exercise-induced bronchoconstriction and to determine the test that best differentiates asthmatics from normal subjects, 10 normal and 15 asthmatic subjects were studied. Allergic status was defined by the presence of one or more positive prick skin tests to 8 common allergens. Pharmacologic sensitivity was defined as the log dose of agonist producing a 20% fall in FEV1 or a 35% fall in specific conductance. Exercise consisted of 6 min of steady-state treadmill exercise at 90% of the age predicted maximal heart rate at a temperature of 22.3 ± 1.1° C (mean ± standard deviation) and humidity of 40.1 ± 13.3%. A high degree of exercise stress was achieved as documented by heart rate (171.5 ± 11.7), O2 consumption (2.19 ± 0.65 L/M), and minute ventilation (77.1 ± 24.0 L). Although histamine and methacholin...