Dim light at night increases depressive-like responses in male C3H/HeNHsd mice
Dim light at night increases depressive-like responses in male C3H/HeNHsd mice
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DOI：
10.1016/j.bbr.2012.12.046
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发表时间：
2013-04-15
影响因子：
2.7
通讯作者：
Nelson, Randy J.
中科院分区：
文献类型：
--
作者：
Fonken, Laura K.;Nelson, Randy J.
自从世纪广泛采用电气照明以来，光暴露的日常模式变得越来越多变。季节性的光照波动、轮班工作和跨子午线旅行都与情绪的变化有关。这些研究暗示了环境照明的波动与抑郁症的发展有关。在这里，我们认为，夜间暴露于光线（LAN）可能与抑郁症有因果关系。将产生夜间褪黑激素的雄性C3H/HeNHsd小鼠圈养在标准光/暗（LD）循环中或暴露于夜间昏暗（5勒克斯）LAN（dLAN）中。在光照条件下四周后，对小鼠进行行为测试，并在研究结束时收集海马组织用于qPCR。这里报道了暴露于dLAN的小鼠在蔗糖快感缺乏和强迫游泳测试中均增加抑郁样反应。与昼行草鼠的研究结果相反，dLAN小鼠在一项依赖于校园的学习和记忆任务中对黑夜中饲养的小鼠进行了模仿。TNF α和IL 1 β基因表达在各组之间没有差异，表明这些促炎细胞因子的变化不会介导dLAN诱导的小鼠抑郁样反应。暴露于dLAN的小鼠海马中BDNF表达减少。这些结果表明，低水平的LAN可以改变小鼠的情绪。这项研究沿着以前的工作暗示局域网作为一个潜在的因素，有助于抑郁症。进一步了解局域网的机制，通过它有助于情绪的变化是重要的特征和治疗抑郁症。(C)2013爱思唯尔有限公司版权所有。
Daily patterns of light exposure have become increasingly variable since the widespread adoption of electrical lighting during the 20th century. Seasonal fluctuations in light exposure, shift-work, and transmeridian travel are all associated with alterations in mood. These studies implicate fluctuations in environmental lighting in the development of depressive disorders. Here we argue that exposure to light at night (LAN) may be causally linked to depression. Male C3H/HeNHsd mice, which produce nocturnal melatonin, were housed in either a standard light/dark (LD) cycle or exposed to nightly dim (5 lux) LAN (dLAN). After four weeks in lighting conditions mice underwent behavioral testing and hippocampal tissue was collected at the termination of the study for qPCR Here were report that mice exposed to dLAN increase depressive-like responses in both a sucrose anhedonia and forced swim test. In contrast to findings in diurnal grass rats, dLAN mice perform comparably to mice housed under dark nights in a hippocampus-dependent learning and memory task. TNF alpha and IL1 beta gene expression do not differ between groups, demonstrating that changes in these pro-inflammatory cytokines do not mediate dLAN induced depressive-like responses in mice. BDNF expression is reduced in the hippocampus of mice exposed to dLAN. These results indicate that low levels of LAN can alter mood in mice. This study along with previous work implicates LAN as a potential factor contributing to depression. Further understanding of the mechanisms through which LAN contributes to changes in mood is important for characterizing and treating depressive disorders. (C) 2013 Elsevier B.V. All rights reserved.