EFFECT OF P-CHLOROAMPHETAMINE AND 5,7-DIHYDROXYTRYPTAMINE ON ROTATION AND DOPAMINE TURNOVER
EFFECT OF P-CHLOROAMPHETAMINE AND 5,7-DIHYDROXYTRYPTAMINE ON ROTATION AND DOPAMINE TURNOVER
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DOI：
10.1016/0006-8993(78)90487-0
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发表时间：
1978-01-01
期刊：
影响因子：
2.9
通讯作者：
SNODGRASS, SR
中科院分区：
文献类型：
--
作者：
GIAMBALVO, CT;SNODGRASS, SR
大鼠中缝正中核(MRN)注射对氯苯丙胺(PCA)或5，7-二羟色胺(DHT)后，皮质和纹状体的5-羟色胺(5-羟色胺)和5-羟基吲哚乙酸(5-HIAA)的摄取减少，但不影响去甲肾上腺素(NE)的摄取。单侧将这些神经毒素注射到MRN可引起对侧旋转，这一作用可被氟哌啶醇阻断。病变的大小与大脑皮层的旋转速度和5-羟色胺周转率的下降有关。旋转速度与皮质5-羟色胺周转减少、纹状体DA[多巴胺]周转增加显著相关。皮质5-羟色胺转移率下降与纹状体DA转移率增加有显著相关性。向黑质[SN]注射DHT产生了与MRN损伤类似的行为和生化变化。在这个模型中，苯丙胺和阿朴吗啡产生相同方向的转弯，而在黑质纹状体通路损伤后，它们具有相反的作用，那里发生突触后DA超敏。突触前的变化似乎决定了这一模型的转向。5-羟色胺能MRN对黑质介导的多巴胺能黑质纹状体通路有抑制作用。
Injections of p-chloroamphetamine (PCA) or 5,7-dihydroxytryptamine (DHT) (after pretreatment with desmethylimipramine) into the rat median raphe nucleus (MRN) caused depletions of 5-HT [5-hydroxytryptamine] and 5-HIAA [5-hydroxyindole acetic acid] in the cortex and striatum, and a decrease of cortical 5-HT uptake without affecting NE [norepinephrine] uptake. Unilateral injections of these neurotoxins into the MRN caused contralateral rotation, which was blocked by haloperidol. The size of the lesion correlated with the rate of rotation and the decrease in 5-HT turnover in the cortex. A significant correlation between the rate of rotation and the decrease in cortical 5-HT turnover, and the increase in striatal DA [dopamine] turnover. There was a significant correlation between the decrease in cortical 5-HT turnover and the increase in striatal DA turnover. Injections of DHT into the SN [substantia nigra] produced similar behavioral and biochemical changes as did the MRN lesions. In this model, amphetamine and apomorphine produce turning in the same direction, whereas they have opposite effects after lesions of the nigrostriatal pathway where postsynaptic DA supersensitivity occurs. Presynaptic changes appear to determine turning in this model. An inhibitory role of the serotonergic MRN on the dopaminergic nigrostriatal pathway mediated via the SN is suggested.