Thiazide Exposure and Cardiovascular Risk in Type 2 Diabetes Mellitus: A Point of Clarification.
Thiazide Exposure and Cardiovascular Risk in Type 2 Diabetes Mellitus: A Point of Clarification.
复制标题
2 型糖尿病患者的噻嗪类药物暴露与心血管风险：需要澄清的一点。
DOI：
10.1161/hypertensionaha.119.14447
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Cooper-DeHoff,RhondaM
中科院分区：
文献类型：
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作者：
Smith,StevenM;Winterstein,AlmutG;Pepine,CarlJ;Cooper-DeHoff,RhondaM
最近发表在《高血压》杂志上的一项分析表明，在参加ACCORD试验(控制糖尿病心血管风险的行动)的糖尿病患者中，使用噻嗪与不使用噻嗪相比，存在额外的心血管不良后果风险。在这里，我们使用相同的公开可用的数据集并遵循他们报告的方法来复制这些发现。我们进一步表明，在最初的分析中，可能存在对噻嗪暴露的错误分类。我们进行替代分析，以纠正这种错误分类，以强调错误分类可能对观察到的暴露(例如，噻嗪)和结果(例如，中风和主要不良心血管事件)之间的关联产生的影响。
A recently published analysis inHypertensionsuggests that thiazide use, versus nonuse, is associated with excess risk of adverse cardiovascular outcomes in patients with diabetes mellitus enrolled in the ACCORD trial (Action to Control Cardiovascular Risk in Diabetes). Here, we replicate these findings using the same publicly available datasets and following their reported methods. We further show that possible misclassification of thiazide exposure exists in the original analysis. We perform alternative analyses that correct for this misclassification to highlight the impact that misclassification can have on observed associations between an exposure (eg, thiazides) and outcomes (eg, stroke and major adverse cardiovascular events).