Predicting proximal femoral strength using structural engineering models
Predicting proximal femoral strength using structural engineering models
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DOI：
10.1097/01.blo.0000164400.37905.22
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发表时间：
2005-08-01
影响因子：
4.2
通讯作者：
Skinner, HB
中科院分区：
文献类型：
--
作者：
Keyak, JH;Kaneko, TS;Skinner, HB
与骨质疏松症和转移性疾病相关的髋部骨折是发病和死亡的主要原因。一种准确、精确的预测股骨近端强度和骨折位置的方法将有助于髋部骨折的研究和临床研究。本研究的目标是开发一种结构建模技术，能够准确预测股骨近端强度；在独立数据集上评估该预测强度的准确性和精确度；并评估该技术预测骨折位置的能力。使用基于计算机断层扫描的三维结构模型和单肢站立型负载下的失效机械测试，研究了有或没有转移性病变的新鲜人类尸体近端股骨。这些模型平均低估了近端股骨强度 444 N，预测强度的精度为 1900 N。因此，预测个体受试者髋部强度的能力主要受到精度水平而非准确度的限制。这种精度水平可能足以满足许多臀部力量的研究。最后，这些模型预测了涉及头下和颈部区域的骨折，与单肢站立型负载下实验产生的大多数骨折一致。
Hip fracture related to osteoporosis and metastatic disease is a major cause of morbidity and mortality. An accurate and precise method of predicting proximal femoral strength and fracture location would be useful for research and clinical studies of hip fracture. The goals of this study were to develop a structural modeling technique that accurately predicts proximal femoral strength; to evaluate the accuracy and precision of this predicted strength on an independent data set; and to evaluate the ability of this technique to predict fracture location. Fresh human cadaveric proximal femora with and without metastatic lesions were studied using computed tomography scan-based three-dimensional structural models and mechanical testing to failure under single-limb stance-type loading. The models understated proximal femoral strength by an average of 444 N, and the precision of the predicted strength was 1900 N. Therefore, the ability to predict hip strength in an individual subject is limited primarily by the level of precision, rather than accuracy. This level of precision is likely to be sufficient for many studies of hip strength. Finally, these models predict fractures involving the subcapital and cervical regions, consistent,with most fractures produced experimentally under single-limb stance-type loading.