Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells.
Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells.
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DOI：
10.1042/bst20190951
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发表时间：
2021-11-01
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
在多细胞生物体中，所有细胞的基因组通常是相同的。程序化DNA消除是这一基因组恒定性规则的一个显著例外。DNA消除去除生殖系基因组中的基因和重复元件，以在各种生物体中形成简化的体细胞基因组。生物体内的DNA消除过程是高度精确和可重复的;它通常发生在早期胚胎发生期间，与生殖细胞体细胞分化一致。DNA消除提供了一种沉默体细胞中选定基因和重复序列的机制。最近在线虫中的研究表明，DNA消除去除了所有染色体末端，解决了性染色体融合，也可能促进新基因的诞生。程序化的DNA消除过程在物种之间是不同的，这表明DNA消除可能在不同的分类群中进化了多次。越来越多的经历DNA消除的生物体的名单表明，DNA消除可能比以前认识到的更广泛。这些不同的生物体将作为补充和比较模型，以研究后生动物中程序化DNA消除的功能，机制和进化。
In a multicellular organism, the genomes of all cells are in general the same. Programmed DNA elimination is a notable exception to this genome constancy rule. DNA elimination removes genes and repetitive elements in the germline genome to form a reduced somatic genome in various organisms. The process of DNA elimination within an organism is highly accurate and reproducible; it typically occurs during early embryogenesis, coincident with germline-soma differentiation. DNA elimination provides a mechanism to silence selected genes and repeats in somatic cells. Recent studies in nematodes suggest that DNA elimination removes all chromosome ends, resolves sex chromosome fusions, and may also promote the birth of novel genes. Programmed DNA elimination processes are diverse among species, suggesting DNA elimination likely has evolved multiple times in different taxa. The growing list of organisms that undergo DNA elimination indicates that DNA elimination may be more widespread than previously appreciated. These various organisms will serve as complementary and comparative models to study the function, mechanism, and evolution of programmed DNA elimination in metazoans.
影响因子：
4.4
作者：
Costa V;Casamassimi A;Roberto R;Gianfrancesco F;Matarazzo MR;D'Urso M;D'Esposito M;Rocchi M;Ciccodicola A
通讯作者：
Ciccodicola A