Effects of noradrenaline and dopamine injected into the supraoptic nucleus on urine flow rate in hydrated rats
Effects of noradrenaline and dopamine injected into the supraoptic nucleus on urine flow rate in hydrated rats
复制标题
视上核注射去甲肾上腺素和多巴胺对水合大鼠尿流率的影响
DOI：
10.1016/0014-4886(78)90173-5
复制
发表时间：
1978
影响因子：
5.3
通讯作者：
Hideshi Kobayashi
中科院分区：
文献类型：
--
作者：
A. Urano;Hideshi Kobayashi
将单胺类药物直接微注射到水合大鼠视上核内，观察其对尿流率的影响。去甲肾上腺素、肾上腺素和5-羟色胺是脑干传入单胺能纤维的递质，它们引起双相反应：最初短暂的利尿和随后的抗利尿，尿流速度迅速下降。多巴胺存在于下丘脑内单胺能纤维中，止于视上核，引起逐渐的抗利尿反应，比去甲肾上腺素引起的反应温和。α-肾上腺素能阻滞剂Phenoxybenzamine在去甲肾上腺素注射前给予视上核抑制去甲肾上腺素的抗利尿反应，但增强利尿反应。二氯异丙肾上腺素，一种β阻滞剂，能阻止去甲肾上腺素的利尿反应，但不能阻止抗利尿反应。我们讨论了视上神经元α-肾上腺素能受体介导释放刺激和β-肾上腺素能受体介导抗利尿激素释放抑制刺激的可能性。
Monoaminergic agents were microinjected directly into the supraoptic nucleus in hydrated rats and the effects on urine flow rate were examined. Noradrenaline, adrenaline, and 5-hydroxytryptamine, transmitters of afferent monoaminergic fibers from the brain stem, caused a biphasic response: initial brief diuresis and subsequent antidiuresis with a rapid fall in the rate of urine flow. Dopamine, which is contained in intrahypothalamic monoaminergic fibers ending in the supraoptic nucleus, elicited a gradual antidiuretic response, milder than that caused by noradrenaline. Phenoxybenzamine, an α-adrenergic blocker, administered to the supraoptic nucleus prior to the injection of noradrenaline inhibited the antidiuretic response to noradrenaline, but enhanced the diuretic response. Dichlorisoproterenol, a β-blocker, prevented the diuretic response to noradrenaline, but not the antidiuretic response. We discuss the possibilities that α-adrenergic receptors of supraoptic neurons mediate the release stimuli and β-adrenergic receptors mediate the inhibitory stimuli for vasopressin release.