GPVI and integrin αIIβ3 signaling in platelets
GPVI and integrin αIIβ3 signaling in platelets
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DOI：
10.1111/j.1538-7836.2005.01429.x
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发表时间：
2005-08-01
影响因子：
10.4
通讯作者：
Pearce, AC
中科院分区：
文献类型：
--
作者：
Watson, SP;Auger, JM;Pearce, AC
这篇综述总结了我们对血小板活化的分子基础的理解的最新进展，这两种不同类型的表面受体，免疫球蛋白GPVI和整合素α IIb β 3（也称为GPIIbIIIa）。这两类受体通过相似但不同的基于酪氨酸激酶的信号级联传递信号，导致磷脂酶C γ 2的活化。这些信号级联在血小板粘附和血小板聚集在动脉剪切率的意义进行了讨论。
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alpha IIb beta 3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase C gamma 2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.