Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe.
Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe.
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DOI：
10.7554/elife.68401
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发表时间：
2021-11-15
期刊：
影响因子：
7.7
通讯作者：
Zaghloul KA
中科院分区：
文献类型：
--
作者：
Tong APS;Vaz AP;Wittig JH;Inati SK;Zaghloul KA
直接脑记录提供了重要的见解，通过颅内脑电图（iEEG）捕获的高频活动如何支持人类记忆检索。然而，这种活动在多大程度上是由反映底层神经元动态协调的瞬时波动组成的，目前尚不清楚。在这里，我们同时记录iEEG，局部场电位（LFP），并在人类颞叶皮层的单单位活动。我们证明，在先前确定的80-120 Hz的涟漪带内的快速振荡有助于在人类皮层的宽带高频活动。这些涟漪振荡表现出与潜在神经元尖峰的量相关的幅度和持续时间的频谱。宏观尺度iEEG中的波纹与微观尺度LFP中波纹的数量和同步性相关，而微观尺度LFP中波纹的数量和同步性又与神经元尖峰发放的同步性相关。我们的数据表明，人类颞叶的神经活动被组织成短暂的涟漪振荡，反映了潜在的尖峰活动爆发。
Direct brain recordings have provided important insights into how high-frequency activity captured through intracranial EEG (iEEG) supports human memory retrieval. The extent to which such activity is comprised of transient fluctuations that reflect the dynamic coordination of underlying neurons, however, remains unclear. Here, we simultaneously record iEEG, local field potential (LFP), and single unit activity in the human temporal cortex. We demonstrate that fast oscillations within the previously identified 80–120 Hz ripple band contribute to broadband high-frequency activity in the human cortex. These ripple oscillations exhibit a spectrum of amplitudes and durations related to the amount of underlying neuronal spiking. Ripples in the macro-scale iEEG are related to the number and synchrony of ripples in the micro-scale LFP, which in turn are related to the synchrony of neuronal spiking. Our data suggest that neural activity in the human temporal lobe is organized into transient bouts of ripple oscillations that reflect underlying bursts of spiking activity.