Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer
Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer
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DOI：
10.1002/ijc.29526
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发表时间：
2015-10-01
影响因子：
6.4
通讯作者：
Kumar, Rajiv
中科院分区：
文献类型：
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作者：
Hosen, Ismail;Rachakonda, P. Sivaramakrishna;Kumar, Rajiv
端粒酶逆转录酶（TERT）和成纤维细胞生长因子受体3（FGFR 3）基因启动子的突变构成了膀胱尿路上皮癌中最常见的体细胞改变。在这项研究中，我们筛选了来自327例尿路上皮膀胱癌患者的DNA，这些患者具有不同的阶段和等级，并且已知TERT启动子突变状态，用于FGFR 3改变并测量相对端粒长度（RTL）。尽管TERT启动子突变的频率高于FGFR 3，但两个位点的突变同时发生的频率高于偶然发生的频率[比值比（OR）=4.93，95%CI =2.72-8.92，p
Mutations in the promoter of the telomerase reverse transcriptase (TERT) and fibroblast growth factor receptor 3 (FGFR3) genes constitute the most recurrent somatic alterations in urothelial carcinoma of bladder. In this study, we screened DNA from 327 urothelial bladder carcinomas from well-documented patients, with different stages and grades and known TERT promoter mutational status, for FGFR3 alterations and measured relative telomere length (RTL). Although, the frequency of the TERT promoter mutations was higher than those in FGFR3; however, the alterations at the two loci occurred together more frequently than per chance [Odds ratio (OR)=4.93, 95% CI=2.72-8.92, p