Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain.
Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain.
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DOI：
10.3389/fnins.2016.00372
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发表时间：
2016
影响因子：
4.3
通讯作者：
Wright DE
中科院分区：
文献类型：
--
作者：
Cooper MA;Kluding PM;Wright DE
在医学界，身体活动作为一种治疗工具的应用正在迅速增长，运动在缓解痛苦的疾病状态方面所发挥的作用是一个新兴的研究领域。神经性疼痛的发展是一个复杂的机制，临床医生和研究人员正在不断努力更好地理解这一机制。可用于缓解这些疼痛状态的有限疗法仍然集中于减轻疼痛，而不是治疗潜在的机制。对运动和疼痛的持续研究可能会解决这些潜在机制，但人们对运动起作用的机制仍然知之甚少。本综述的目的是概述周围神经系统如何对运动做出反应、炎症与运动的关系以及运动治疗疼痛的实验和临床应用。尽管疼痛与许多疾病有关，但这篇综述强调了与糖尿病相关的疼痛以及与神经损伤相关的疼痛的实验研究。由于运动对多个器官系统的整体影响，运动干预可以通过单次干预解决整个神经系统的多个问题。然而，这是一把双刃剑，因为运动的全球相互作用还需要深入研究，以包括和识别体育活动后可能发生的许多变化。有必要继续投资研究，以推动身体活动作为治疗神经性疼痛的有益疗法。以下重点介绍了我们目前对运动如何改变疼痛的理解、用于探索运动干预的各种疼痛模型以及导致运动干预后生理和病理变化的分子途径。
The utilization of physical activity as a therapeutic tool is rapidly growing in the medical community and the role exercise may offer in the alleviation of painful disease states is an emerging research area. The development of neuropathic pain is a complex mechanism, which clinicians and researchers are continually working to better understand. The limited therapies available for alleviation of these pain states are still focused on pain abatement and as opposed to treating underlying mechanisms. The continued research into exercise and pain may address these underlying mechanisms, but the mechanisms which exercise acts through are still poorly understood. The objective of this review is to provide an overview of how the peripheral nervous system responds to exercise, the relationship of inflammation and exercise, and experimental and clinical use of exercise to treat pain. Although pain is associated with many conditions, this review highlights pain associated with diabetes as well as experimental studies on nerve damages-associated pain. Because of the global effects of exercise across multiple organ systems, exercise intervention can address multiple problems across the entire nervous system through a single intervention. This is a double-edged sword however, as the global interactions of exercise also require in depth investigations to include and identify the many changes that can occur after physical activity. A continued investment into research is necessary to advance the adoption of physical activity as a beneficial remedy for neuropathic pain. The following highlights our current understanding of how exercise alters pain, the varied pain models used to explore exercise intervention, and the molecular pathways leading to the physiological and pathological changes following exercise intervention.