PATHWAYS OF PROTEIN SECRETION IN EUKARYOTES
PATHWAYS OF PROTEIN SECRETION IN EUKARYOTES
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DOI：
10.1126/science.2994224
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
KELLY, RB
中科院分区：
文献类型：
--
作者：
KELLY, RB
细胞的蛋白质分泌可以采取几种形式。如果蛋白质的分泌与它们的合成一样快，则分泌是组成型的。在调节分泌中，新合成的蛋白质以高浓度储存在分泌囊泡中，直到细胞接受适当的刺激。当组成性和调节性蛋白质分泌都可以在同一细胞中发生时，必须存在将正确的分泌蛋白分选到正确的分泌囊泡中的机制。然后，分泌囊泡必须被递送到质膜的适当区域。将编码外源分泌蛋白的DNA转染到受调节的分泌细胞中提供了对分选成分泌囊泡的特异性的了解。
Protein secretion from cells can take several forms. Secretion is constitutive if proteins are secreted as fast as they are synthesized. In regulated secretion newly synthesized proteins destined for secretion are stored at high concentration in secretory vesicles until the cell receives an appropriate stimulus. When both constitutive and regulated protein secretion can take place in the same cell a mechanism must exist for sorting the correct secretory protein into the correct secretory vesicle. The secretory vesicle must then be delivered to the appropriate region of plasma membrane. Transfection of DNA encoding foreign secretory proteins into regulated secretory cells has provided insight into the specificity of sorting into secretory vesicles.