Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
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DOI：
10.4269/ajtmh.2011.11-0003
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发表时间：
2011-05-01
影响因子：
3.3
通讯作者：
Cappello, Michael
中科院分区：
文献类型：
--
作者：
Humphries, Debbie;Mosites, Emily;Cappello, Michael
在加纳北金坦波的62个家庭的292名受试者中进行了钩虫感染的横断面初步研究。钩虫感染的总患病率为45%，在11-20岁人群中达到高峰（58.5%）。在儿童中，钩虫感染的危险因素包括合并感染疟疾和血清免疫球蛋白G对钩虫分泌抗原的反应性增加。成人感染的风险因素包括营养状况差、不使用厕所、不穿鞋和职业（农业）。虽然阿苯达唑治疗与82%的总体卵子减少率相关，但仍有37名受试者（39%）仍感染。在治疗失败的患者中，治疗与卵子排泄的显着减少无关，近三分之一的患者在重复检查时计数较高。这些数据证实了加纳中部低强度钩虫感染的高流行率及其与营养状况不良的关系。阿苯达唑的高失败率引起了人们对新出现的耐药性的关注。
A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence of hookworm infection was 45%, peaking in those 11-20 years old (58.5%). In children, risk factors for hookworm infection included coinfection with malaria and increased serum immunoglobulin G reactivity to hookworm secretory antigens. Risk factors for infection in adults included poor nutritional status, not using a latrine, not wearing shoes, and occupation (farming). Although albendazole therapy was associated with an overall egg reduction rate of 82%, 37 subjects (39%) remained infected. Among those who failed therapy, treatment was not associated with a significant reduction in egg excretion, and nearly one-third had higher counts on repeat examination. These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance.