Vitamin D insufficiency in North America
Vitamin D insufficiency in North America
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DOI：
10.1093/jn/135.2.332
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发表时间：
2005-02-01
影响因子：
4.2
通讯作者：
Davison, KS
中科院分区：
文献类型：
--
作者：
Hanley, DA;Davison, KS
维生素D不足是一个术语，用来描述缺乏维生素D的生化证据，没有明显的临床体征或症状，如佝偻病或骨软化症。该病最常诊断为血清25-羟基维生素D低于40 nmol/L（16马克杯/L）。本文回顾了北美的研究，解决了这个问题的普遍性，以及越来越多的证据表明维生素D不足会使个体的骨骼和肌肉健康状况不佳。“维生素D不足”这个词有点误导人，因为这种情况的患者实际上只是维生素D缺乏症的一部分。如果使用更宽泛的定义（血清25-羟基维生素D < 80 nmol/L），则有更大比例的人群存在问题。临床试验中对维生素D补充的反应表明，目前推荐的这种维生素的膳食摄入量过低，应该推荐更高的摄入量。
Vitamin D insufficiency is a term that has been used to describe the finding of biochemical evidence of deficiency, without obvious clinical signs or symptoms, such as rickets or osteomalacia. The condition is most commonly diagnosed by a serum 25-hydroxyvitamin D below 40 nmol/L (16 mug/L). This paper reviews North American studies addressing the prevalence of the problem, and the growing body of evidence that vitamin D insufficiency predisposes individuals to poor bone and muscle health. The term insufficiency is somewhat misleading, as patients with this condition are really just part of the spectrum of vitamin D deficiency. If the more generous definition of this condition is used (serum 25-hydroxyvitamin D < 80 nmol/L), a much larger proportion of the population has the problem. The response to vitamin D supplementation in clinical trials suggests current recommendations for dietary intake of this vitamin are too low and that a higher adequate intake should be recommended.