Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest.
Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest.
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DOI：
10.1038/s41598-017-17686-3
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发表时间：
2017-12-20
影响因子：
4.6
通讯作者：
Ishizawa K
中科院分区：
文献类型：
--
作者：
Niimura T;Zamami Y;Koyama T;Izawa-Ishizawa Y;Miyake M;Koga T;Harada K;Ohshima A;Imai T;Kondo Y;Imanishi M;Takechi K;Fukushima K;Horinouchi Y;Ikeda Y;Fujino H;Tsuchiya K;Tamaki T;Hinotsu S;Kano MR;Ishizawa K
关于心脏骤停后给予氢化可的松的报道很少，已发表的报道包括的受试者很少。本研究旨在评价氢化可的松给药对心脏骤停患者结局的影响。我们调查了存活出院率和从心脏骤停到出院的住院时间，使用氢化可的松分层，使用日本健康保险索赔数据集，覆盖约2%的日本人口。该研究纳入了2005年1月至2014年5月期间发生院内或院外心脏骤停的2233例受试者的数据。这些患者被分为两组，根据氢化可的松的管理。我们使用通过治疗加权法的逆概率获得的倾向评分调整了两组的基线特征、药物治疗和药物给药数据。氢化可的松组的存活出院率显著更高（13/61 [21.1%] vs. 240/2172 [11.0%]，校正比值比：4.2，95% CI：1.60-10.98，p = 0.004）。此外，氢化可的松的给药是存活至出院的独立预测因子（风险比：4.6，p < 0.001）。结果表明，氢化可的松的管理和高利率的生存出院之间的相关性。
There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60–10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.
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影响因子：
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作者：
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120.7
作者：
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通讯作者：
Zakynthinos, Spyros G.