The contribution of dormant origins to genome stability: From cell biology to human genetics
The contribution of dormant origins to genome stability: From cell biology to human genetics
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DOI：
10.1016/j.dnarep.2014.03.012
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发表时间：
2014-07-01
期刊：
影响因子：
3.8
通讯作者：
Blow, J. Julian
中科院分区：
文献类型：
--
作者：
Alver, Robert C.;Chadha, Gaganmeet Singh;Blow, J. Julian
真核细胞精确复制其 DNA 的能力对于维持基因组稳定性至关重要。在这里，我们描述了我们目前对 DNA 复制许可起源的过程的理解，并回顾了最近的工作，表明叉停顿对许可起源的定位施加了强大的选择压力。有鉴于此，我们讨论了在小鼠模型和人类患者中观察到的由于复制许可蛋白缺陷而出现的复杂且不同的表型。 (C) 2014 年作者。由 Elsevier B.V. 出版
The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins. (C) 2014 The Authors. Published by Elsevier B.V.