Decreased regional brain metabolism after ECT
Decreased regional brain metabolism after ECT
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DOI：
10.1176/appi.ajp.158.2.305
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发表时间：
2001-02-01
影响因子：
17.7
通讯作者：
Mann, JJ
中科院分区：
文献类型：
--
作者：
Nobler, MS;Oquendo, MA;Mann, JJ
目的：电痉挛疗法的抗抑郁作用可能与其抗惊厥作用有关。正电子发射断层扫描（PET）研究区域脑代谢率葡萄糖被用来验证这一假设。方法：对10例重度抑郁症患者进行双侧电痉挛治疗前后约5天的PET观察。统计参数映射用于识别脑糖代谢降低的区域。结果：电刺激后发现广泛的脑糖代谢区域下降，特别是在额、顶叶皮层、扣带回前后和左颞叶皮层。感兴趣区域分析同样显示ect后区域脑葡萄糖代谢减少。结论：电痉挛疗法降低了特定皮质区域的神经元活动，具有潜在的抗惊厥和抗抑郁作用。
Objective: The antidepressant action of ECT may be related to its anticonvulsant properties. Positron emission tomography (PET) studies of regional cerebral metabolic rate for glucose were used to test this hypothesis.Method: Ten patients with major depression were studied with PET before and approximately 5 days after a course of bilateral ECT. Statistical parametric mapping was used to identify regions of decreased cerebral glucose metabolism.Results: Widespread regions of decreased regional cerebral glucose metabolism were identified after ECT, especially in the frontal and parietal cortex, anterior and posterior cingulate gyrus, and left temporal cortex. A region-of-interest analysis similarly indicated post-ECT reductions in regional cerebral glucose metabolism.Conclusions: ECT reduces neuronal activity in selected cortical regions, a potential anticonvulsant and antidepressant effect.